received an overall rating of 6 out of 10 stars from 10 reviews. Sulfasalazine is a disease-modifying antirheumatic drug used in the treatment of AS. Tablet, Gastro-resistant tablet, Oral suspension, Suppository Sulfasalazine can cause male infertility by reducing the sperm count, but this usually reverses once the drug is stopped. Speak to your rheumatology team about this if you have any concerns. Serum levels should be monitored every three months, and more frequently at the outset. The use of sulfasalazine in inflammatory bowel disease has declined due mainly to the fact that it yields the metabolite sulfapyridine which gives rise to side-effects such as agranulocytosis and hypospermia. Less common or rare side effects. Serum levels above 50 μg/l are associated with side effects. you can start either HCQ or Methotrexate on this place. The most common side effect is stomach upset – nausea, vomiting, loss of appetite, and diarrhoea. Sulfasalazine is used to manage the symptoms of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. In males, a lowered sperm count can … Avoid direct or prolonged exposure to sunlight. Sulfsalazine metabolizes to sulfapyridine. Nervous tissue involvement may produce inflammation and pain along with hearing disturbances, hearing loss or lack of physical coordination. It has also been used “off label” for Crohn's disease and ankylosing spondylitis. (NB. Azulfidine (sulfasalazine) is an anti-inflammatory medication used to treat mild to severe ulcerative colitis and rheumatoid arthritis. Some side effects may be serious, although they are not common. Sulfasalazine dose. In rare cases, Sulfasalazine can cause severe depression in young males. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Common side effects of Azulfidine include gastrointestinal disturbances, headache, allergic reactions, rash when exposed to sunlight, and changes in skin or urine color. You may prefer to take an alternative aminosalicylate that does not have this side effect. Like all medicines, sulfasalazine can cause side effects, but not everyone gets them. If side effects are severe, it can be tapered more slowly. Immune thrombocytopenia has been reported. Salazopyrin EN-tabs contain the active ingredient sulfasalazine, which is a type of medicine called an aminosalicylate. Sulfasalazine can also cause … It can also be used to treat other diseases such as psoriatic arthritis, Crohn's disease and ulcerative colitis. Since sulfasalazine may cause haemolytic anaemia, it should be used with caution in patients with G-6-PD deficiency. Sulfasalazine (brand names Pyralin EN, Salazopyrin EN) is a medicine - a combination of an aspirin-like anti-inflammatory component and a sulphur antibiotic-like component - used to treat rheumatoid arthritis. It can also cause temporary infertility. In fact, an estimated 25% of all ED is a side effect of drugs, according to the Harvard Special Health Report Erectile Dysfunction: How medication, lifestyle changes, and other therapies can help you conquer this vexing problem. Effects of Sulfasalazine (SSZ): Sulfasalazine metabolizes to sulfapyridine. Also nausea for the initial 4 weeks. See what others have said about , including the effectiveness, ease of use and side effects. Serum levels above 50 μg/l are associated with side effects. Sulfasalazine and its metabolite, sulfapyridine, pass through the placenta. Sulfasalazine is considered safe to use while you are breastfeeding, unless the baby is premature or at risk of jaundice. 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