Milk Thistle seeds contain the highest concentrations of the active compound, silymarin. One study has shown that milk thistle seed extract has estrogenic effects and effects on memory by estrogen. As Little Bear said, milk thistle can cause a reaction in those with a rag weed allergy - like me. Also, as they said, it's use is for protecting and detoxing the liver. Milk thistle is a herbal drug that has been used for thousands of years to treat many different health problems. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Other uses not proven with research have included treating malaria , mushroom poisoning , spleen or gallbladder problems, menstrual problems, liver problems (such as … Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Milk thistle (Silybum marianum) is an herbal remedy that has long been used in Iran. Typical, everyday stresses can seem even more overwhelming than before the start of menopause. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Depression and anxiety are associated with increased risk of developing AD. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Some research also talks about the importance of milk thistle in treating anxiety and depression – but we need more information on this before we come to conclusions. Milk thistle is generally considered safe when taken by mouth (1, 45). Sleepiness, depression, personality changes, erratic behavior, psychosis, extreme fatigue, and all kinds of other symptoms can happen from excessive ammonia if not cleared out of the body, especially from the blood brain barrier. So it would be unusual for it alone to be responsible relieving gastro issues, but I sure wouldn't say … Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Taking milk thistle with this hepatitis C medication might increase levels of the drug in your blood plasma. Milk thistle may reduce anxiety and improve depression. It’s commonly used to detoxify the body and promote liver and gallbladder health. In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects ( 1 ). The authors of this study note that silybin shows promise in memory impairment diseases.3 Some even claim that milk thistle is effective in treating depression and anxiety, but there’s not enough research to support these claims. As a woman prepares to end her childbearing years, hormonal changes take place. Simeprevir. 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